TUBA4A Polyclonal Antibody (CABC014)

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CABC014
  • Immunohistochemistry - TUBA4A Polyclonal Antibody (CABC014)
  • Immunofluorescence - TUBA4A Polyclonal Antibody (CABC014)
  • Immunohistochemistry - TUBA4A Polyclonal Antibody (CABC014)
  • Immunohistochemistry - TUBA4A Polyclonal Antibody (CABC014)
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Description

TUBA4A Polyclonal Antibody (CABC014)

Overview

Title:TUBA4A Polyclonal Antibody (CABC014)
Size:100uL
Code:CABC014
Host Species:Rabbit
Purification:Affinity purification
Isotype:IgG

Background

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Immunogen Information

Immunogen:Recombinant protein of human TUBA4A
GeneID:7277
SwissProt:P68366
Synonyms:TUBA4A; ALS22; H2-ALPHA; TUBA1; tubulin alpha 4a
Calculated MW:48kDa/49kDa
Observed MW:Refer to figures

Applications

Reactivity:Human, Mouse, Rat
Tested Applications:WB; IHC; IF;
Recommended Dilution:WB 1:500 - 1:2000; IHC 1:25 - 1:50; IF 1:25 - 1:100
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application Key:Western blotting    Immunohistochemistry    Immunofluorescence    
Positive Samples:
Cellular Location:Cytoplasm, cytoskeleton

Antibody Images

Immunohistochemistry - TUBA4A Polyclonal Antibody (CABC014)

Immunohistochemistry of paraffin-embedded rat brain using TUBA4A Antibody (CABC014) at dilution of 1:100 (40x lens).

Immunohistochemistry - TUBA4A Polyclonal Antibody (CABC014)

Immunohistochemistry of paraffin-embedded rat kidney using TUBA4A Antibody (CABC014) at dilution of 1:100 (40x lens).

Immunohistochemistry - TUBA4A Polyclonal Antibody (CABC014)

Immunohistochemistry of paraffin-embedded rat heart using TUBA4A Antibody (CABC014) at dilution of 1:100 (40x lens).

Immunofluorescence - TUBA4A Polyclonal Antibody (CABC014)

Immunofluorescence analysis of HeLa cells using TUBA4A antibody (CABC014). Blue: DAPI for nuclear staining.

TUBA4A Polyclonal Antibody (CABC014) Protein Information

UniProt Protein Function:TUBA4A: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. Belongs to the tubulin family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: microtubule; extracellular region; cytosol

Molecular Function:GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton

Biological Process: protein polymerization; 'de novo' posttranslational protein folding; platelet activation; cellular protein metabolic process; platelet degranulation; protein folding; organelle organization and biogenesis; mitotic cell cycle; G2/M transition of mitotic cell cycle; blood coagulation; microtubule-based process

Disease: Amyotrophic Lateral Sclerosis 22 With Or Without Frontotemporal Dementia

NCBI Summary:Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
UniProt Code:P68366
NCBI GenInfo Identifier:55977476
NCBI Gene ID:7277
NCBI Accession:P68366.1
UniProt Related Accession:P68366
Molecular Weight:50kDa
NCBI Full Name:Tubulin alpha-4A chain
NCBI Synonym Full Names:tubulin alpha 4a
NCBI Official Symbol:TUBA4A  
NCBI Official Synonym Symbols:ALS22; TUBA1; H2-ALPHA  
NCBI Protein Information:tubulin alpha-4A chain
UniProt Protein Name:Tubulin alpha-4A chain
UniProt Synonym Protein Names:Alpha-tubulin 1; Testis-specific alpha-tubulin; Tubulin H2-alpha; Tubulin alpha-1 chain
Protein Family:Tubulin
UniProt Gene Name:TUBA4A  
UniProt Entry Name:TBA4A_HUMAN
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Additional Information

ANTIBODY TYPE:
Polyclonal
APPLICATION:
WB
APPLICATION:
IHC
APPLICATION:
IF
REACTIVITY:
Human
REACTIVITY:
Mouse
REACTIVITY:
Rat
HOST SPECIES:
Rabbit
ISOTYPE:
IgG
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