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Phospho-TP53-S46 pAb (CABP0161)

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SKU:
CABP0161
$476.19

Description

Overview

Title:Phospho-TP53-S46 pAb (CABP0161)
Size:100µL
Code:CABP0161
Host Species:Rabbit
Purification:Affinity purification
Isotype:IgG

Background

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).

Immunogen Information

Immunogen:A phospho specific peptide corresponding to residues surrounding S46 of human TP53
GeneID:7157
SwissProt:P04637
Synonyms:TP53; BCC7; LFS1; P53; TRP53; tumor protein p53
Calculated MW:23-43kDa
Observed MW:55kDa

Applications

Reactivity:Human
Tested Applications:WB
Recommended Dilution:WB 1:500 - 1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application Key:Western blotting    
Positive Samples:MCF-7
Cellular Location:Cytoplasm, Endoplasmic reticulum, Mitochondrion matrix, Nucleus, PML body

Antibody Images

Western blot - Phospho-TP53-S46 pAb (CABP0161)

Western blot analysis of extracts from MCF cells, using phospho-TP53-S46 antibody (CABP0161).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% BSA.

Datasheets

Antibody DatasheetAntibody MSDS

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Additional Information

Antibody Type:
Polyclonal
Application:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
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