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LRRK2 Polyclonal Antibody (CAB10959)

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SKU:
CAB10959
€299.00

Description

Overview

Title:LRRK2 Polyclonal Antibody (CAB10959)
Size:100µL
Code:CAB10959
Host Species:Rabbit
Purification:Affinity purification
Isotype:IgG

Background

This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.

Immunogen Information

Immunogen:A synthetic peptide of human LRRK2
GeneID:120892
SwissProt:Q5S007
Synonyms:LRRK2; AURA17; DARDARIN; PARK8; RIPK7; ROCO2; leucine rich repeat kinase 2
Calculated MW:286kDa
Observed MW:286kDa

Applications

Reactivity:Human
Tested Applications:WB; IHC; FC
Recommended Dilution:WB 1:500 - 1:1000; IHC 1:20 - 1:50; FC 1:20 - 1:50
Storage Buffer:Store at 4°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, pH7.3.
Application Key:Western blotting    Immunohistochemistry    Flow Cytometry    
Positive Samples:LO2, A-549, 293T, Jurkat
Cellular Location:Cell projection, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, Mitochondrion, Mitochondrion inner membrane, Mitochondrion matrix, Mitochondrion outer membrane, Perikaryon, Peripheral membrane protein, axon, dendrite, secretory vesicle, synaptic vesicle membrane

Antibody Images

Western blot - LRRK2 Polyclonal Antibody (CAB10959)

Western blot analysis of extracts of various cell lines, using LRRK2 antibody (CAB10959) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.

Datasheets

Antibody DatasheetAntibody MSDS

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Additional Information

Antibody Type:
Polyclonal
Application:
WB
Application:
IHC
Application:
FC
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
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