ERVW-1 Polyclonal Antibody (CAB16522)
- SKU:
- CAB16522
Description
| Title: | ERVW-1 Polyclonal Antibody (CAB16522) | |
| Size: | 100µL | |
| Code: | CAB16522 | |
| Host Species: | Rabbit | |
| Purification: | Affinity purification | |
| Isotype: | IgG |
Background
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Immunogen Information
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ERVW-1 (NP_001124397.1). |
| GeneID: | 30816 |
| SwissProt: | Q9UQF0 |
| Synonyms: | ERVW-1; ENV; ENVW; ERVWE1; HERV-7q; HERV-W-ENV; HERV7Q; HERVW; HERVWENV; syncytin-1 |
| Calculated MW: | 59kDa |
| Observed MW: | 55kDa |
Applications
| Reactivity: | Human, Mouse |
| Tested Applications: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Application Key: | Western blotting |
| Positive Samples: | U-251MG, 293T, mouse brain |
| Cellular Location: | Cell membrane, Peripheral membrane protein, Single-pass type I membrane protein, Virion |
Antibody Images
| Western blot analysis of extracts of various cell lines, using ERVW-1 antibody (CAB16522) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s. |
Datasheets
Additional Information
Antibody Type: |
Polyclonal |
Application: |
WB |
Reactivity: |
Human |
Reactivity: |
Mouse |
Host Species: |
Rabbit |
Isotype: |
IgG |
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