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CD2AP Polyclonal Antibody (CAB7788)

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SKU:
CAB7788
€299.00

Description

Overview

Title:CD2AP Polyclonal Antibody (CAB7788)
Size:100µL
Code:CAB7788
Host Species:Rabbit
Purification:Affinity purification
Isotype:IgG

Background

This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.

Immunogen Information

Immunogen:A synthetic peptide of human CD2AP
GeneID:23607
SwissProt:Q9Y5K6
Synonyms:CD2AP; CMS; CD2-associated protein
Calculated MW:71kDa
Observed MW:71kDa

Applications

Reactivity:Human, Mouse, Rat
Tested Applications:WB
Recommended Dilution:WB 1:500 - 1:2000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application Key:Western blotting    
Positive Samples:A-431, Raji, MCF-7, SW480, NCI-H460, Mouse kidney, Rat kidney
Cellular Location:Cell projection, Cytoplasm, cytoskeleton, ruffle

Antibody Images

Western blot - CD2AP Polyclonal Antibody (CAB7788)

Western blot analysis of extracts of various cell lines, using CD2AP antibody (CAB7788) at 1:500 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 60s.

Datasheets

Antibody DatasheetAntibody MSDS

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Additional Information

Antibody Type:
Polyclonal
Application:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
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