The cookie settings on this website are set to 'allow all cookies' to give you the very best experience. Please click Accept Cookies to continue to use the site.

C10orf2 Polyclonal Antibody (CAB13433)

(No reviews yet) Write a Review
SKU:
CAB13433
$331.89

Description

Overview

Title:C10orf2 Polyclonal Antibody (CAB13433)
Size:100µL
Code:CAB13433
Host Species:Rabbit
Purification:Affinity purification
Isotype:IgG

Background

This gene encodes a hexameric DNA helicase which unwinds short stretches of double-stranded DNA in the 5' to 3' direction and, along with mitochondrial single-stranded DNA binding protein and mtDNA polymerase gamma, is thought to play a key role in mtDNA replication. The protein localizes to the mitochondrial matrix and mitochondrial nucleoids. Mutations in this gene cause infantile onset spinocerebellar ataxia (IOSCA) and progressive external ophthalmoplegia (PEO) and are also associated with several mitochondrial depletion syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Immunogen Information

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 600 to the C-terminus of human C10orf2 (NP_068602.2).
GeneID:56652
SwissProt:Q96RR1
Synonyms:TWNK; ATXN8; C10orf2; IOSCA; MTDPS7; PEO; PEO1; PEOA3; PRLTS5; SANDO; SCA8; TWINL; twinkle mtDNA helicase
Calculated MW:60kDa/66kDa/77kDa
Observed MW:77kDa

Applications

Reactivity:Mouse
Tested Applications:WB
Recommended Dilution:WB 1:500 - 1:2000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application Key:Western blotting    
Positive Samples:Mouse kidney
Cellular Location:Mitochondrion matrix, mitochondrion nucleoid

Antibody Images

Western blot - C10orf2 Polyclonal Antibody (CAB13433)

Western blot analysis of extracts of mouse kidney, using C10orf2 antibody (CAB13433) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

Datasheets

Antibody DatasheetAntibody MSDS

View AllClose

Additional Information

Antibody Type:
Polyclonal
Application:
WB
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
View AllClose