Investigating the Role of BRD3 as a Novel Therapeutic Target in Invasive Lobular Carcinoma

By Kate Haley, Post-Doc, RCSI At present, the field of biomedical science is replete with researchers endeavoring to unveil molecular mechanisms which will improve our understanding of disease pathogenesis and in turn be translated into the clinic as therapeutic strategies. The advent of translational research, nearly 10 years ago now, was marked by a call for […]

Early Diagnosis is key: Pick the weed or allow it destroy the garden?

By Catríona Dowling, Post-Doc, RCSI I want you to come on a journey with me where we are going to the botanic gardens. You will pick a section of the garden that is yours: yours to treasure and nourish. If a weed started to grow in that garden, would you chose to ignore the weed […]

HERV-K group of endogenous retroviruses and cancer

In 2006, upon completion of the Human Genome Project, it was discovered that nearly 8% of the human genome is made up of viral DNA. These viral remnants are composed of ancient germline infections known as human endogenous retroviruses (HERVs) which are passed on to future generations in a Mendelian fashion1–4. Although these viral elements […]

The double-edged sword in prostate cancer therapy

By Zoe Angel, PhD student, Ulster University Prostate cancer is now the commonest cancer in men and it is the fifth leading cause of death (1). Researchers have strived to understand its development and extraordinary progress has been made in the last 50 years. Better treatments for this disease have been developed and the outlook is […]

Microcalcifications in breast cancer: Novel insights into the molecular mechanism and functional consequences

By Shane O’Grady, PhD student, RCSI Cancer is a disease that will, unfortunately, touch all of our lives at some point, directly or indirectly. Despite decades of gradual, hard-won incremental improvements to available treatment options, survival is still strongly associated with the stage at which a tumour is first detected: patients diagnosed with stage 4 […]

Human Papilloma Virus (HPV) primary screening process using methylation analysis

By Stephen Reynolds, PhD Student, CERVIVA and Trinity College Dublin We hear almost daily now how everyone in their lifetime will be touched by cancer either directly or through a close family member. Cancer is our modern plague but even though it is so prevalent in modern society every cancer type is unique whether it […]

Cancer Research Club – RCSI

Our Cancer Research Club symposium series continued on Wednesday afternoon, at Royal College of Surgeons (RCSI), Dublin, Ireland. The Bouchier-Hayes lecture theatre was at maximum capacity with over 60 scientists from all major universities and Institutes in Ireland coming together to network around the theme of “The Tumor Microenvironment”. This event was organised by Dr. […]

Androgenic steroid action in breast cancer

By Rachel Bleach, PhD Student, RCSI By the age of 79 years, 1 in 14 women will develop breast cancer (Global Burden of Disease Cancer 2017). Beatson reported on the utility of removing the ovaries in the treatment of advanced breast cancer in 1896, leading to the observation that estrogen is one of the driving […]

How we can target the underlying immune processes in pathological inflammation in obesity, cancer and liver disease.

By Dr. Melissa Conry, TTMI I am an immunologist and senior research fellow in the Cancer Immunology and Immunotherapy Group, Department of Surgery at Trinity College Dublin. My research is focused on developing novel immunotherapies in the space of obesity, cancer and liver disease with a specific focus on lymphocyte trafficking and chemokine networks. My […]

How the tumor microenvironment alters T-cell acute leukaemia

By Alessandra Di Grande, PhD Student, RCSI – Antibody Genie Young Researcher Award 2018 (PhD category) Leukaemia is a blood cancer arising from the malignant transformation of the white blood cells. The white blood cells fight infection from bacteria and viruses within the body. The incidence rate of leukaemia in Europe is 82,274 a year […]