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AVP Polyclonal Antibody (CAB1725)

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CAB1725
  • Western blot - AVP Polyclonal Antibody (CAB1725)
  • Immunohistochemistry - AVP Polyclonal Antibody (CAB1725)
$331.89

Description

Overview

Title:AVP Polyclonal Antibody (CAB1725)
Size:100µL
Code:CAB1725
Host Species:Rabbit
Purification:Affinity purification
Isotype:IgG

Background

This gene encodes a member of the vasopressin/oxytocin family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the neuropeptide hormone arginine vasopressin, and two other peptides, neurophysin 2 and copeptin. Arginine vasopressin is a posterior pituitary hormone that is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI). This gene is present in a gene cluster with the related gene oxytocin on chromosome 20.

Immunogen Information

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-164 of human AVP (NP_000481.2).
GeneID:551
SwissProt:P01185
Synonyms:AVP; ADH; ARVP; AVP-NPII; AVRP; VP; arginine vasopressin
Calculated MW:17kDa
Observed MW:17kDa

Applications

Reactivity:Human, Mouse, Rat
Tested Applications:WB; IHC
Recommended Dilution:WB 1:500 - 1:2000; IHC 1:50 - 1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application Key:Western blotting    Immunohistochemistry    
Positive Samples:U-87MG, LO2, Mouse brain, Mouse lung, Rat brain, Rat lung
Cellular Location:Secreted

Antibody Images

Western blot - AVP Polyclonal Antibody (CAB1725)

Western blot analysis of extracts of various cell lines, using AVP antibody (CAB1725) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.

Immunohistochemistry - AVP Polyclonal Antibody (CAB1725)

Immunohistochemistry of paraffin-embedded rat brain using AVP antibody (CAB1725) at dilution of 1:100 (40x lens).

Datasheets

Antibody DatasheetAntibody MSDS

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Additional Information

Antibody Type:
Polyclonal
Application:
WB
Application:
IHC
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
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