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ATM Polyclonal Antibody (CAB15645)

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SKU:
CAB15645
€299.00

Description

Overview

Title:ATM Polyclonal Antibody (CAB15645)
Size:100µL
Code:CAB15645
Host Species:Rabbit
Purification:Affinity purification
Isotype:IgG

Background

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

Immunogen Information

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1900-2000 of human ATM (NP_000042.3).
GeneID:472
SwissProt:Q13315
Synonyms:ATM; AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1; serine-protein kinase ATM
Calculated MW:350kDa
Observed MW:N/A

Applications

Reactivity:Human, Rat
Tested Applications:IF
Recommended Dilution:IF 1:50 - 1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application Key:Immunofluorescence    
Positive Samples:N/A
Cellular Location:Cytoplasmic vesicle, Nucleus

Antibody Images

Immunofluorescence - ATM Polyclonal Antibody (CAB15645)

Immunofluorescence analysis of U2OS cells using ATM antibody (CAB15645) at dilution of 1:100. Blue: DAPI for nuclear staining.

Datasheets

Antibody DatasheetAntibody MSDS

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Additional Information

Antibody Type:
Polyclonal
Application:
IF
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
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