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ATF2 Polyclonal Antibody (CAB0756)

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SKU:
CAB0756
$331.89

Description

Overview

Title:ATF2 Polyclonal Antibody (CAB0756)
Size:100µL
Code:CAB0756
Host Species:Rabbit
Purification:Affinity purification
Isotype:IgG

Background

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene

Immunogen Information

Immunogen:A synthetic peptide of human ATF2
GeneID:1386
SwissProt:P15336
Synonyms:ATF2; CRE-BP1; CREB-2; CREB2; HB16; TREB7; activating transcription factor 2
Calculated MW:13- 15kDa/23-24kDa/35-54kDa
Observed MW:20kDa

Applications

Reactivity:Human, Mouse
Tested Applications:WB
Recommended Dilution:WB 1:200 - 1:500
Storage Buffer:Store at 4°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, pH7.3.
Application Key:Western blotting    
Positive Samples:HeLa
Cellular Location:Cytoplasm, Mitochondrion outer membrane, Nucleus

Antibody Images

Western blot - ATF2 Polyclonal Antibody (CAB0756)

Western blot analysis of extracts of HeLa cells, using ATF2 antibody (CAB0756).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.

Datasheets

Antibody DatasheetAntibody MSDS

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Additional Information

Antibody Type:
Polyclonal
Application:
WB
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
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