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AIPL1 Polyclonal Antibody (CAB14113)

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CAB14113
  • Western blot - AIPL1 Polyclonal Antibody (CAB14113)
  • Immunofluorescence - AIPL1 Polyclonal Antibody (CAB14113)
€299.00

Description

Overview

Title:AIPL1 Polyclonal Antibody (CAB14113)
Size:100µL
Code:CAB14113
Host Species:Rabbit
Purification:Affinity purification
Isotype:IgG

Background

Leber congenital amaurosis (LCA) is the most severe inherited retinopathy with the earliest age of onset and accounts for at least 5% of all inherited retinal diseases. Affected individuals are diagnosed at birth or in the first few months of life with nystagmus, severely impaired vision or blindness and an abnormal or flat electroretinogram. The photoreceptor/pineal-expressed gene, AIPL1, encoding aryl-hydrocarbon interacting protein-like 1, is located within the LCA4 candidate region. The encoded protein contains three tetratricopeptide motifs, consistent with chaperone or nuclear transport activity. Mutations in this gene may cause approximately 20% of recessive LCA. Alternative splicing results in multiple transcript variants.

Immunogen Information

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-384 of human AIPL1 (NP_055151.3).
GeneID:23746
SwissProt:Q9NZN9
Synonyms:AIPL1; AIPL2; LCA4; aryl-hydrocarbon-interacting protein-like 1
Calculated MW:36kDa/40kDa/41kDa/43kDa
Observed MW:40-55kDa

Applications

Reactivity:Human, Mouse, Rat
Tested Applications:WB; IF
Recommended Dilution:WB 1:500 - 1:2000; IF 1:50 - 1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application Key:Western blotting    Immunofluorescence    
Positive Samples:U-937, Mouse liver, Mouse heart, Rat liver, Rat brain
Cellular Location:Cytoplasm, Nucleus

Antibody Images

Western blot - AIPL1 Polyclonal Antibody (CAB14113)

Western blot analysis of extracts of various cell lines, using AIPL1 antibody (CAB14113) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.

Immunofluorescence - AIPL1 Polyclonal Antibody (CAB14113)

Immunofluorescence analysis of MCF7 cells using AIPL1 antibody (CAB14113). Blue: DAPI for nuclear staining.

Datasheets

Antibody DatasheetAntibody MSDS

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Additional Information

Antibody Type:
Polyclonal
Application:
WB
Application:
IF
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
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