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AF/LE Purified Human CD28 Monoclonal Antibody [CD28.2](AGEL2019)

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SKU:
AGEL2019
$681.54

Description

Overview:

Title:AF/LE Purified Human CD28 Monoclonal Antibody
Host Species:Mouse
Size:1 mg
Volume Per Test:1mg/mL

Background:

CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation.

Antibody Information:

Isotype:IgG2a, ?
GeneID:940
SwissProt:P10747
Synonyms:PAS2,MNS,HGpMiX,GYPA,GPSAT
Clone:CD28.2
Conjugation:Azide Free/Low endotoxin

Applications:

Reactivity:Human
Tested Applications:Activ, FC, IHC, IP
Recommended Dilution:Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ? 2.0 µg per 10e6 cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage Buffer:0.2 µm filtered in PBS, pH7.2. Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg (<0.002EU/?g) as Determined by LAL gel clotting assay. Purity is >95% as determined by SDS-PAGE
Storage:Store at 2~8?. Do not freeze.
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