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AF/LE Purified Human CD279/PD-1 Monoclonal Antibody [J116](AGEL1606)

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SKU:
AGEL1606
$911.31

Description

Overview:

Title:AF/LE Purified Human CD279/PD-1 Monoclonal Antibody
Host Species:Mouse
Size:1 mg
Volume Per Test:1mg/mL

Background:

Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.

Antibody Information:

Isotype:IgG2a, ?
GeneID:5133
SwissProt:Q15116
Synonyms:PD-1, Programmed Death-1
Clone:J116
Conjugation:Azide Free/Low endotoxin

Applications:

Reactivity:Human
Tested Applications:Block, Neut, FC,IHC,IP
Recommended Dilution:Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ? 2.0 µg per 10e6 cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage Buffer:0.2 µm filtered in PBS, pH7.2. Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg (<0.002EU/?g) as Determined by LAL gel clotting assay. Purity is >95% as determined by SDS-PAGE
Storage:Store at 2~8?. Do not freeze.
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