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AF/LE Purified Human CD274/PD-L1 Monoclonal Antibody [29E.2A3](AGEL1645)

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SKU:
AGEL1645
$911.31

Description

Overview:

Title:AF/LE Purified Human CD274/PD-L1 Monoclonal Antibody
Host Species:Mouse
Size:1 mg
Volume Per Test:1mg/mL

Background:

CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-gamma production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

Antibody Information:

Isotype:IgG2a, ?
GeneID:29126
SwissProt:Q9NZQ7
Synonyms:B7-H1, PD-L1,Programmed cell death ligand 1,B7 homolog 1,B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1
Clone:29E.2A3
Conjugation:Azide Free/Low endotoxin

Applications:

Reactivity:Human
Tested Applications:Block, FA, FC, IHC
Recommended Dilution:Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ? 2.0 µg per 10e6 cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage Buffer:0.2 µm filtered in PBS, pH7.2. Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg (<0.002EU/?g) as Determined by LAL gel clotting assay. Purity is >95% as determined by SDS-PAGE
Storage:Store at 2~8?. Do not freeze.
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