ACVRL1 Polyclonal Antibody (CAB1791)

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CAB1791
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Description

Antibody DatasheetAntibody MSDS

ACVRL1 Polyclonal Antibody (CAB1791)

Overview

Title:ACVRL1 Polyclonal Antibody (CAB1791)
Size:100µL
Code:CAB1791
Host Species:Rabbit
Purification:Affinity purification
Isotype:IgG

Background

This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.

Immunogen Information

Immunogen:Recombinant protein of human ACVRL1
GeneID:94
SwissProt:P37023
Synonyms:ACVRL1; ACVRLK1; ALK-1; ALK1; HHT; HHT2; ORW2; SKR3; TSR-I; activin A receptor like type 1
Calculated MW:56kDa
Observed MW:65kDa

Applications

Reactivity:Human, Mouse, Rat
Tested Applications:WB
Recommended Dilution:WB 1:500 - 1:2000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application Key:Western blotting    
Positive Samples:SH-SY5Y, HL-60, MCF-7, Jurkat, Mouse lung, Mouse heart, Mouse liver, Rat brain
Cellular Location:Membrane, Single-pass type I membrane protein

Antibody Images

Western blot - ACVRL1 Polyclonal Antibody (CAB1791)

Western blot analysis of extracts of various cell lines, using ACVRL1 antibody (CAB1791) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

ACVRL1 Polyclonal Antibody (CAB1791) Protein Information

UniProt Protein Function:ALK1: a kinase of the STKR family. A type I cell-surface receptor for the TGF-beta superfamily of ligands including Activin A. Highly expressed in human placenta and lung. Deficiency causes hemorrhagic telangiectasia type 2 also known as Rendu-Osler-Weber syndrome 2.
UniProt Protein Details:

Protein type:EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type1 subfamily

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: cell surface; integral to plasma membrane; plasma membrane

Molecular Function:activin binding; activin receptor activity, type I; ATP binding; protein binding; protein kinase binding; protein serine/threonine kinase activity; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor activity; transforming growth factor beta receptor activity, type I

Biological Process: angiogenesis; blood circulation; blood vessel endothelial cell proliferation during sprouting angiogenesis; blood vessel maturation; blood vessel remodeling; BMP signaling pathway; lymphangiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of cell adhesion; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of focal adhesion formation; positive regulation of BMP signaling pathway; positive regulation of chondrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; regulation of blood pressure; regulation of blood vessel endothelial cell migration; regulation of DNA replication; regulation of endothelial cell proliferation; regulation of transcription, DNA-dependent; signal transduction; transforming growth factor beta receptor signaling pathway; wound healing, spreading of epidermal cells

Disease: Telangiectasia, Hereditary Hemorrhagic, Type 2

NCBI Summary:This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]
UniProt Code:P37023
NCBI GenInfo Identifier:3915750
NCBI Gene ID:94
NCBI Accession:P37023.2
UniProt Secondary Accession:P37023,A6NGA8,
UniProt Related Accession:P37023
Molecular Weight:56,124 Da
NCBI Full Name:Serine/threonine-protein kinase receptor R3
NCBI Synonym Full Names:activin A receptor like type 1
NCBI Official Symbol:ACVRL1  
NCBI Official Synonym Symbols:HHT; ALK1; HHT2; ORW2; SKR3; ALK-1; TSR-I; ACVRLK1  
NCBI Protein Information:serine/threonine-protein kinase receptor R3
UniProt Protein Name:Serine/threonine-protein kinase receptor R3
UniProt Synonym Protein Names:Activin receptor-like kinase 1; ALK-1; TGF-B superfamily receptor type I; TSR-I
Protein Family:Serine/threonine-protein kinase haspin
UniProt Gene Name:ACVRL1  
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Additional Information

Antibody Type:
Polyclonal
Application:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
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