ACSM2A Polyclonal Antibody (CAB15563)

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CAB15563
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Description

Antibody DatasheetAntibody MSDS

ACSM2A Polyclonal Antibody (CAB15563)

Overview

Title:ACSM2A Polyclonal Antibody (CAB15563)
Size:100µL
Code:CAB15563
Host Species:Rabbit
Purification:Affinity purification
Isotype:IgG

Background

This gene encodes a mitochondrial acyl-coenzyme A synthetase that is specific for medium chain fatty acids. These enzymes catalyze fatty acid activation, the first step of fatty acid metabolism, through the transfer of acyl-CoA. These enzymes also participate in the glycine conjugation pathway in the detoxification of xenobiotics such as benzoate and ibuprofen. Expression levels of this gene in the kidney may be correlated with kidney function. This gene and its paralog ACSM2B (Gene ID: 348158), both present on chromosome 16, likely arose from a chromosomal duplication event.

Immunogen Information

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 418-577 of human ACSM2A (NP_001295101.1).
GeneID:123876
SwissProt:Q08AH3
Synonyms:ACSM2A; A-923A4.1; ACSM2; acyl-coenzyme A synthetase ACSM2A, mitochondrial
Calculated MW:64kDa
Observed MW:64kDa

Applications

Reactivity:Mouse, Rat
Tested Applications:WB
Recommended Dilution:WB 1:200 - 1:2000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application Key:Western blotting    
Positive Samples:N/A
Cellular Location:Mitochondrion matrix

Antibody Images

Western blot - ACSM2A Polyclonal Antibody (CAB15563)

Western blot analysis of extracts of various cell lines, using ACSM2A antibody (CAB15563) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.

ACSM2A Polyclonal Antibody (CAB15563) Protein Information

UniProt Protein Function:ACSM2A: an acyl-CoA synthetase. Acyl-CoA synthetases catalyze the first reaction of amino acid conjugation in fatty acid metabolism and of many xenobiotic carboxylic acids. A liver enzyme implicated in the metabolism of xenobiotic carboxylic acids such as pesticides, arylpropionate anti-inflammatory drugs and hypolipidaemic clofibrate and its congeners.
UniProt Protein Details:

Protein type:Mitochondrial; Ligase; EC 6.2.1.2; Carbohydrate Metabolism - butanoate

Chromosomal Location of Human Ortholog: 16p12.3

Molecular Function:butyrate-CoA ligase activity

UniProt Code:Q08AH3
NCBI GenInfo Identifier:257050995
NCBI Gene ID:123876
NCBI Accession:Q08AH3.2
UniProt Secondary Accession:Q08AH3,O75202, B3KTT9,
UniProt Related Accession:Q08AH3
Molecular Weight:64,223 Da
NCBI Full Name:Acyl-coenzyme A synthetase ACSM2A, mitochondrial
NCBI Synonym Full Names:acyl-CoA synthetase medium-chain family member 2A
NCBI Official Symbol:ACSM2A  
NCBI Official Synonym Symbols:ACSM2; A-923A4.1  
NCBI Protein Information:acyl-coenzyme A synthetase ACSM2A, mitochondrial
UniProt Protein Name:Acyl-coenzyme A synthetase ACSM2A, mitochondrial
UniProt Synonym Protein Names:Acyl-CoA synthetase medium-chain family member 2A; Butyrate--CoA ligase 2A; Butyryl-coenzyme A synthetase 2A; Middle-chain acyl-CoA synthetase 2A
Protein Family:Acyl-coenzyme A synthetase
UniProt Gene Name:ACSM2A  
UniProt Entry Name:ACS2A_HUMAN
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Additional Information

Antibody Type:
Polyclonal
Application:
WB
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
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